Organic Synthesis on Solid Phase. Supports, Linkers, Reactions PDF

Organic synthesis on solid supports is a rapidly developing methodology, which offers several advantages if compared to traditional synthesis in solution. In recent years the number of substance classes that can be synthesised on solid phase has quickly increased, and solid-phasesynthesis is becoming a valuable alternative to traditional synthesis - in particular when large numbers of different compounds in small quantities are needed for screening.This exhaustive and systematically organised reference work gives an in-depth view on organic syntheses on insoluble polymers from the basic principles to the newest developments. The work quickly guides the reader to any particular type of reaction and to the best method for preparing a given class of compounds on solid support.Many tables with clear presentations collect valuable information about the feasibility of a given reaction on solid support, and a wealth of information is opened up to the reader through a thoroughly worked out and comprehensive reference list. This makes the book the first stop when it comes to synthesising your compounds on solid support.

While solid-phase organic synthesis (SPOS) has partially met the need [63], several drawbacks still handicap its use, e.g. the lengthy reaction times resulting from the use of heterogeneous